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Open Letter
on
the Research
of Marijuana

By Punkerslut,
to the National Cannabis Prevention
and Information Centre (NCPIC)

Photograph of Marijuana
Image: Released under the GNU
Free Documentation License,
Version 1.2

Start Date: March 17, 2010
Finish Date: March 17, 2010

Dear NCPIC:

     There are some comments that need to be made in response to the article "respiratory effects of cannabis," by Peter Gates. In his article, he quotes a variety of researchers... all very badly. His intention was to prove that Marijuana, when used by a human being, produces negative effects. The scientific spirit, which is based on empiricism, would have tested this hypothesis. It wouldn't have danced around it. Marijuana, when burnt, produces toxic chemicals -- like every other known substance on this planet. This was the study quoted by Gates done by Hoffmann, D., Brunneman, D.K., Gori, G.B., & Wynder, E.L.. Or, for instance, another study shows that Marijuana users hold their breath in deeper, possibly causing more damage.

     Reading through the article made me more and more aggravated. Why not test the ground where marijuana grows, to see if it eating the dirt is toxic? Why not test to see if ingesting over a hundred kilograms of it is healthy? Why not even go so far as to see if Marijuana can be used by terrorists as an explosive, or if it has inappropriate sexual dreams about its mother? They're all mildly interesting areas of research. But if you're going to write an article, about how Marijuana causes lung cancer, I have one question: what people have used Marijuana and gotten lung cancer? Your article provided absolutely no resources. Scientists in a lab, messing around with chemicals, showing that this or that is harmful -- big deal. I want to see the experiment that directly relates to the claim. Everything else gets in the way.

     There are some "studies" that allegedly followed Marijuana users. But these are done by scientists and researchers who have previously rigged studies, or canceled studies for coming up with the "wrong effect." It was 1974, at the Medical College of Virginia, where the US government canned a research project for demonstrating that marijuana cures cancer. Other studies mentioned by Gates are completely worthless, for the reasons he admits himself, "...however the need for further study on the respiratory effects of smoking cannabis with a non-tobacco smoking group remains." They're so completely worthless and just the propaganda of established governments and states.

     Why even waste time on those studies? We DO HAVE STUDIES TODAY that follow the scientific model, that have been done by honest researchers. For instance, D.P. Tashkin. You thought he was good enough to quote him about a study that shows that you produce more phlegm when you smoke marijuana. But why not publish a study by him that shows among more than a thousand, that people who use Marijuana only HAVE LESS CHANCE OF CANCER? [ "Study finds no marijuana-lung cancer link," Reuters, Wednesday, May 24, 2006; Posted: 2:11 p.m. EDT (18:11 GMT). ]

     There is a very obvious reason why you refuse to publish reliable studies, why you withhold the facts, why you're admittedly forcing questionable and dubious facts onto the public: because your organization, and those that support you, want to suppress Marijuana. Even with studies where people using marijuana could cure their cancer, you bring up these old studies. You bring up scientists playing with fire and smoke in their labs, and then you believe them then they say that embers in their laboratory means marijuana is toxic to your body. Unscientific -- over and over again, this is my claim about mainstream organizations that refuse to look Marijuana as a cure-all to humanity's physical and social problems. A list of studies, conducted on those with cancer and not by smoke and mirrors state-researchers, has been attached to this e-mail.

     Tell people the truth, and if you're not sure about that, then let them decide for themselves. Quoting some openly biased, fixed studies about Marijuana use, and then saying that "better studies don't exist," *IS* lying about it. Whether you like it or not, you're playing a role in fighting the only potential cure for cancer right now. And by the time you're able to live up to that, maybe you'll see that it's the only potential cure for society's ills, as well.

     Thank you, and I'm hoping for a response.

Sincerely,
Andy Carloff

Resources

1. Oncogene. 2008 Jan 10;27(3):339-46. Epub 2007 Jul 9. "Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo." By Preet A, Ganju RK, Groopman JE; Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

2. Journal of the National Cancer Institute, 2007. "Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1." By Robert Ramer, Burkhard Hinz; Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany.

3. Cancer Res. 2008 August 1; 68(15): 64686476. "Loss of cannabinoid receptor 1 accelerates intestinal tumor growth." By Dingzhi Wang,1 Haibin Wang,2 Wei Ning,1 Michael G. Backlund,1 Sudhansu K. Dey,2,3,4 and Raymond N. DuBois5,6*; 1) Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6838. 2) Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-6838. 3) Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232-6838. 4) Department of Cell & Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-6838. 5) Vanderbilt-Ingram Cancer Center, Nashville, TN 37232-6838. 6) Departments of Gastrointestinal Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030. Selection quoted from "Marijuana Takes on Colon Cancer," by Aria Pearson, August 2008, New Scientist.

4. Published in 2007, November, Molecular Cancer Therapeutics. Quoted from "Cannabis Compound May Stop Metastatic Breast Cancer," by Carolyn Colwell, U.S. News, 11/19/2007.

5. "Marijuana May Stall Brain Tumor Growth: Active Ingredient in Marijuana Inhibits Cancer Growth in Early Study," By Jennifer Warner, WebMD Health News, Reviewed by Michael W. Smith, MD, Aug. 15, 2004.

6. "Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells," Sean D. Mc Allister Contact Information, Calvin Chan, Ryan J. Taft, Tri Luu, Mary E. Abood, Dan H. Moore, Ken Aldape and Garret Yount, California Pacific Medical Center Research Institute, 475 Brannan St., Suite 220, San Francisco, CA 94107, USA, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Volume 74, Number 1 / August, 2005.

7. "Inhibition of tumor angiogenesis by cannabinoids," The FASEB Journal. 2003;17:529-531. CRISTINA BL ZQUEZ2, M. LLANOS CASANOVA*,2, ANNA PLANAS{dagger}, TERESA G MEZ DEL PULGAR, CONCEPCI N VILLANUEVA{ddagger}, MAR A J. FERN NDEZ-ACE ERO{ddagger}, JULI N ARAGON S , JOHN W. HUFFMAN||, JOS L. JORCANO* and MANUEL GUZM N3, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain; * Project on Cellular and Molecular Biology and Gene Therapy, CIEMAT, Madrid, Spain; {dagger} Department of Pharmacology and Toxicology, IIBB-CSIC, IDIBAPS, Barcelona, Spain; {ddagger} Department of Pathology, Hospital General de M stoles, Madrid, Spain; Department of Immunology, Hospital de la Princesa, Madrid, Spain; and || Department of Chemistry, Clemson University, Clemson, South Carolina, USA, 3Correspondence: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain, January 2, 2003.

8. "Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines," First published on November 14, 2003; DOI: 10.1124/jpet.103.061002, Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P. Abbracchio, and Daniela Parolaro.

9. "Mechanism of Extracellular Signal-Regulated Kinase Activation by the CB1 Cannabinoid Receptor," Ismael Galve-Roperh, Daniel Rueda, Teresa G mez del Pulgar, Guillermo Velasco, and Manuel Guzm n, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain. Molecular Pharmacology, Vol. 62, Issue 6, 1385-1392, December 2002.

10. Life Sciences, Volume 77, Issue 14, 19 August 2005, Pages 1723-1731. "Cannabinoids and ceramide: Two lipids acting hand-by-hand," by Guillermo Velasco, Ismael Galve-Roperh, Cristina S nchez, Cristina Bl zquez, Amador Haro and Manuel Guzm nCorresponding Author Contact Information, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain. 14 June 2005.

11. "Antineoplastic activity of cannabinoids," Journal of the National Cancer Institute, Vol. 55, No. 3, September 1975, pp.597-602, by A.E. Munson, L.S. Harris, M.A. Friedman, W.L. Dewey, and R.A. Carchman.


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